A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.
basic_science · Level V
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- Record sourced from PubMed, PMID 24923560.
- Also identified by DOI 10.1371/journal.pone.0099493 and PMC identifier 4055699.
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Abstract
The chromosomal translocation t(4;14) deregulates MMSET (WHSC1/NSD2) expression and is a poor prognostic factor in multiple myeloma (MM). MMSET encodes two major protein isoforms. We have characterized the role of the shorter isoform (REIIBP) in myeloma cells and identified a clear and novel interaction of REIIBP with members of the SMN (survival of motor neuron) complex that directly affects the assembly of the spliceosomal ribonucleic particles. Using RNA-seq we show that REIIBP influences the RNA splicing pattern of the cell. This new discovery provides novel insights into the understanding of MM pathology, and potential new leads for therapeutic targeting.
Medical subject headings
- Histone-Lysine N-Methyltransferase
- RNA Processing, Post-Transcriptional
- Repressor Proteins
- SMN Complex Proteins