Virology. Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24926010.
- Also identified by DOI 10.1126/science.1254082.
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Abstract
Lucifora et al. (Research Articles, 14 March 2014, p. 1221) report that the hepatitis B virus (HBV) transcriptional template, a long-lived covalently closed circular DNA (cccDNA) molecule, is degraded noncytolytically by agents that up-regulate APOBEC3A and 3B. If these results can be independently confirmed, they would represent a critical first step toward development of a cure for the 400 million patients who are chronically infected by HBV.
Medical subject headings
- Antiviral Agents
- DNA, Circular
- DNA, Viral
- Hepatitis B
- Hepatitis B virus
- Hepatocytes
- Interferon-alpha
- Lymphotoxin beta Receptor