Virology. Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".
Where this comes from
- Record sourced from PubMed, PMID 24926011.
- Also identified by DOI 10.1126/science.1254083.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.
Medical subject headings
- Antiviral Agents
- DNA, Circular
- DNA, Viral
- Hepatitis B
- Hepatitis B virus
- Hepatocytes
- Interferon-alpha
- Lymphotoxin beta Receptor