Clinical and neuroimaging findings in neonatal herpes simplex virus infection.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 24929330.
- Also identified by DOI 10.1016/j.jpeds.2014.04.046.
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Abstract
In a retrospective review of infants with neonatal herpes simplex virus disease (n=29), we found bilateral multilobar (n=8), pontine (n=3), thalamic (n=6), and internal capsule and corticospinal tract (n=5) involvement on magnetic resonance imaging (MRI). Diffusion-weighted imaging (n=6) performed early revealed additional involvement than detected by conventional MRI. Neurodevelopmental sequelae were correlated with MRI abnormalities. Our findings demonstrate that MRI, including diffusion-weighted imaging, is a valuable prognostic adjunct in neonatal herpes simplex virus disease.
Medical subject headings
- Brain
- Encephalitis, Herpes Simplex
- Herpes Simplex
- Neuroimaging
- Pregnancy Complications, Infectious
- Simplexvirus