The Scramble conversion tool.

Bonfield, James K · Bioinformatics · 2014

other · Level V

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Abstract

The reference CRAM file format implementation is in Java. We present 'Scramble': a new C implementation of SAM, BAM and CRAM file I/O. The C implementation of for CRAM is 1.5-1.7× slower than BAM at decoding but 1.8-2.6× faster at encoding. We see file size savings of 34-55%. Source code is available at http://sourceforge.net/projects/staden/files/io_lib/ under the BSD software licence.

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