Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24934192.
- Also identified by DOI 10.1038/nrrheum.2014.95 and PMC identifier 10859036.
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Abstract
IL-21 regulates the activity and number of IL-10-producing regulatory B cells (B10 cells) that modulate immune responses and limit diverse autoimmune diseases. A new study demonstrates that IL-35 has a similar function. Identifying regulatory circuits that control B10-cell function in vivo might open the door to future treatments for autoimmune diseases.
Medical subject headings
- Autoimmune Diseases
- Autoimmunity
- B-Lymphocytes, Regulatory
- Interleukin-10
- Interleukins