Loss of P2Y₁₄ results in an arresting response to hematological stress.
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- Record sourced from PubMed, PMID 24937422.
- Also identified by DOI 10.1172/JCI76626 and PMC identifier 4071389.
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Abstract
The regenerative capacity of tissues to recover from injury or stress is dependent on stem cell competence, yet the underlying mechanisms that govern how stem cells detect stress and initiate appropriate responses are poorly understood. In this issue of the JCI, Cho and Yusuf et al. demonstrate that the purinergic receptor P2Y14 may mediate the hematopoietic stem and progenitor cell regenerative response.
Medical subject headings
- Hematopoietic Stem Cells
- Receptors, Purinergic P2Y