Secretory vesicles deliver Cdc42p to sites of polarized growth in S. cerevisiae.
basic_science · Level V
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- Record sourced from PubMed, PMID 24945395.
- Also identified by DOI 10.1371/journal.pone.0099494 and PMC identifier 4063767.
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Abstract
The activation and localization of the Rho-family GTPase Cdc42p at one pole of a cell is necessary for maintaining an axis of polarized growth in many animal and fungal cells. How the asymmetric distribution of this key regulator of polarized morphogenesis is maintained is not fully understood, though divergent models have emerged from a congruence of multiple studies, including one that posits a role for polarized secretion. Here we show with S. cerevisiae that Cdc42p associates with secretory vesicles in vivo.
Medical subject headings
- Endoplasmic Reticulum
- Phosphoproteins
- Saccharomyces cerevisiae
- Secretory Vesicles
- cdc42 GTP-Binding Protein, Saccharomyces cerevisiae