Shedding "UV" light on endogenous opioid dependence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24949960.
- Also identified by DOI 10.1016/j.cell.2014.06.009 and PMC identifier 9840560.
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Abstract
Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and produces an endogenous opioid-dependent state.
Medical subject headings
- Behavior, Addictive
- Skin
- beta-Endorphin