Oligomeric nanoparticles functionalized with NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imaging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24952975.
- Also identified by DOI 10.1016/j.biomaterials.2014.05.071.
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Abstract
We report herein the facile surface-functionalization of one type of biocompatible, oligomeric nanoparticles 1-NPs with NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imaging in vivo. The -NH2 and -SH groups of cysteine residues on the 1-NPs were utilized to covalently conjugate CdTe/CdS QDs and Mal-FA to prepare the hybrid nanoparticles 1-NPs-QDs-FA. As-prepared 1-NPs-QDs-FA showed NIR-fluorescence emission at 734 nm, selective uptake by FR-overexpressing tumor cells in vitro, and selective FR-overexpressing tumor-targeted imaging in vivo. This first example of oligomeric/inorganic hybrid nanoparticles provides people with new type of biomaterials for tumor-targeted imaging with high selectivity.
Medical subject headings
- Cadmium Compounds
- Diagnostic Imaging
- Folic Acid
- Nanoparticles
- Neoplasms
- Quantum Dots
- Spectroscopy, Near-Infrared
- Sulfides
- Tellurium