TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24954262.
- Also identified by DOI 10.1016/j.jaci.2014.05.019 and PMC identifier 4186904.
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Abstract
IL-17 and TNF<b>α</b> synergistically induce surface expression of IL-13R<b>α</b>2 on primary lung fibroblasts, rendering them unresponsive to IL-13. Neutralizing antibodies to IL-13R<b>α</b>2 restored IL-13-mediated signaling and transcriptome studies confirmed IL-13R<b>α</b>2 is an IL-13 decoy receptor.
Medical subject headings
- Asthma
- Fibroblasts
- Interleukin-13
- Interleukin-13 Receptor alpha2 Subunit
- Interleukin-17
- Lung
- Tumor Necrosis Factor-alpha