Science to practice: Cellular therapy of Parkinson disease--a new radiotracer to target transplanted dopaminergic cells with PET.
Level V
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- Record sourced from PubMed, PMID 24956043.
- Also identified by DOI 10.1148/radiol.14140548.
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Abstract
The article by Bu and colleagues (1) introduces N-[2-(diethylamino)ethyl]-(18)F-5-fluoropicolinamide ((18)F-P3BZA) as a promising positron emission tomography (PET) radiotracer to target transplanted porcine retinal pigment epithelial (pRPE) cells in the striatum. This strategy to monitor cellular therapy of Parkinson disease has a high translational potential and in the future may help us to better understand some of the controversial results reported in clinical trials.
Medical subject headings
- Fluorine Radioisotopes
- Molecular Imaging
- Multimodal Imaging
- Parkinson Disease
- Picolinic Acids
- Positron-Emission Tomography
- Radiopharmaceuticals
- Retinal Pigment Epithelium
- Tomography, X-Ray Computed