Efficient induction of apoptosis by wee1 kinase inhibition in hepatocellular carcinoma cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 24960176.
- Also identified by DOI 10.1371/journal.pone.0100495 and PMC identifier 4069002.
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Abstract
Transforming growth factor-β1 (TGF-β1) potently inhibits human hepatocellular carcinoma (HCC) cell growth. Here we demonstrated that TGF-β1-induced apoptosis is mediated by decreased phosphorylation of cdc2 at Tyr15 accompanied by down-regulation of Wee1 kinase expression. As expected from these results, a Wee1 kinase inhibitor efficiently induced apoptosis in HCC cells in the absence of TGF-β1 treatment. In surgically resected samples, Wee1 kinase was expressed in moderately to poorly differentiated HCC, whereas no Wee1 kinase expression was observed in non-cancerous tissue, including cirrhotic tissue. Our results suggest that Wee1 kinase inhibitors may be a practical novel therapeutic option against advanced HCC.
Medical subject headings
- Apoptosis
- Carcinoma, Hepatocellular
- Cell Cycle Proteins
- Liver Neoplasms
- Nuclear Proteins
- Protein Kinase Inhibitors
- Protein-Tyrosine Kinases