Systemic regulation of mammalian ageing and longevity by brain sirtuins.
review · Level V
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- Record sourced from PubMed, PMID 24967620.
- Also identified by DOI 10.1038/ncomms5211 and PMC identifier 4521907.
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Abstract
Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hypothalamus, in governing multiple physiological functions. These data provide strong evidence that brain sirtuins regulate mammalian ageing and longevity at the organismal level.
Medical subject headings
- Aging
- Hypothalamus
- Longevity
- Sirtuins