HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 24968937.
- Also identified by DOI 10.1126/science.1254194 and PMC identifier 4262401.
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Abstract
The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five infected individuals on cART. About 40% of the integrations were in clonally expanded cells. Approximately 50% of the infected cells in one patient were from a single clone, and some clones persisted for many years. There were multiple independent integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. Our findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells.
Medical subject headings
- Basic-Leucine Zipper Transcription Factors
- HIV
- HIV Infections
- Transcription Factors
- Virus Integration
- Virus Latency