Fabrication of corona-free nanoparticles with tunable hydrophobicity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24971670.
- Also identified by DOI 10.1021/nn5006478 and PMC identifier 4215884.
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Abstract
A protein corona is formed at the surface of nanoparticles in the presence of biological fluids, masking the surface properties of the particle and complicating the relationship between chemical functionality and biological effects. We present here a series of zwitterionic NPs of variable hydrophobicity that do not adsorb proteins at moderate levels of serum protein and do not form hard coronas at physiological serum concentrations. These particles provide platforms to evaluate nanobiological behavior such as cell uptake and hemolysis dictated directly by chemical motifs at the nanoparticle surface.
Medical subject headings
- Hydrophobic and Hydrophilic Interactions
- Nanoparticles
- Nanotechnology