Cerebrospinal fluid aquaporin-4 antibody levels in neuromyelitis optica attacks.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 24977390.
- Also identified by DOI 10.1002/ana.24208 and PMC identifier 4173125.
- Licence recorded as CC BY-NC.
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Abstract
To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks.
Medical subject headings
- Aquaporin 4
- Autoantibodies
- Neuromyelitis Optica