Phenotypic characteristics of diabetic kidney involvement.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24978373.
- Also identified by DOI 10.1038/ki.2013.552 and PMC identifier 4076684.
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Abstract
Understanding phenotypic characteristics of the diabetic kidney is important for the development of therapies to prevent progression of diabetic nephropathy. In addition to glomerular hyperfiltration and kidney growth, major metabolic abnormalities characterize the diabetic kidney. Increased kidney oxygen consumption leads to cortical and medullary hypoxia in diabetes. Decreasing inspired oxygen to 10% reduces pO2, while oxygen consumption remains elevated, lactate increases, and redox potential decreases, but only in the diabetic kidney--a shift to Warburg metabolism.
Medical subject headings
- Altitude
- Diabetic Nephropathies
- Kidney
- Oxygen Consumption