Protective effect of Artemisia annua L. extract against galactose-induced oxidative stress in mice.
basic_science · Level V
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- Record sourced from PubMed, PMID 24988450.
- Also identified by DOI 10.1371/journal.pone.0101486 and PMC identifier 4079707.
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Abstract
Artemisia annua L. (also called qinghao) has been well known as a source of antimalarial drug artemisinins. In addition, the herb was reported to have in vitro antioxidative activity. The present study investigated the protective effect of aqueous ethanol extract of Qinghao (AA extract) against D-galactose-induced oxidative stress in C57BL/6J mice. Feeding AA extract-containing diet lowered serum levels of malondialdehyde and 8-OH-dG that are biomarkers for lipid peroxidation and DNA damage, respectively. Furthermore, AA extract feeding enhanced the activity of NQO1, a typical antioxidant marker enzyme, in tissues such as kidney, stomach, small intestine, and large intestine. In conclusion, AA extract was found to have antioxidative activity in mouse model.
Medical subject headings
- Antioxidants
- Artemisia annua
- Galactose
- Oxidative Stress
- Plant Extracts