Too little mTORC1 activity injures the liver.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24988455.
- Also identified by DOI 10.1016/j.cmet.2014.06.005.
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Abstract
Obesity promotes chronic activation of mTORC1 and is a known risk factor for hepatic injury, inflammation, and carcinogenesis. In this issue, Umemura et al. (2014) demonstrate that a persistent reduction in hepatic mTORC1 activity also promotes cell damage and inflammation and sensitizes the liver to cancer development.
Medical subject headings
- Inflammation
- Liver
- Multiprotein Complexes
- Sirolimus
- TOR Serine-Threonine Kinases