Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24988456.
- Also identified by DOI 10.1016/j.cmet.2014.06.012 and PMC identifier 4095871.
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Abstract
Mitochondrial DNA diseases are relatively common, sometimes devastating, and transmitted exclusively through the egg to children of carrier mothers. A study in Cell by Wang et al. (2014) adds the exciting possibility of a new therapy for preventing mitochondrial disease transmission predicated on the use of polar body genomes in mice.
Medical subject headings
- Mitochondrial Diseases
- Nuclear Transfer Techniques
- Oocytes
- Polar Bodies