Mitobolites: the elixir of life.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 24988457.
- Also identified by DOI 10.1016/j.cmet.2014.06.013 and PMC identifier 4103626.
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Abstract
One of the biggest challenges in biology is to understand how mitochondria influence aging and age-related diseases. Chin et al. (2014) reveal how a mitochondrial metabolite (mitobolite) inhibits mitochondrial ATPase and extends lifespan by mimicking dietary restriction in worms.
Medical subject headings
- Caenorhabditis elegans
- Ketoglutaric Acids
- Longevity
- Mitochondrial Proton-Translocating ATPases
- TOR Serine-Threonine Kinases