SnapShot: sirtuins, NAD, and aging.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24988458.
- Also identified by DOI 10.1016/j.cmet.2014.06.001.
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Abstract
Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD)-dependent enzymes that regulate a wide range of biological processes, including aging, in several species. This SnapShot provides a comprehensive overview of the targets, enzymatic activities, and physiological functions of the seven mammalian sirtuins, as well as the regulation of the biosynthetic pathways regulating NAD availability.
Medical subject headings
- Aging
- NAD
- Sirtuins