Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24989480.
- Also identified by DOI 10.1002/adhm.201400252 and PMC identifier 4282613.
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Abstract
Arrays of 3D macroporous collagen scaffolds with orthogonal gradations of structural and biomolecular cues are described. Gradient maker technology is applied to create linear biomolecular gradients within microstructurally distinct sections of a single CG scaffold array. The array set up is used to explore cell behaviors including proliferation and regulation of stem cell fate.
Medical subject headings
- Collagen
- Fibroblasts
- Mesenchymal Stem Cells
- Microfluidic Analytical Techniques
- Tissue Array Analysis