A mitochondrial expatriate: nuclear pyruvate dehydrogenase.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24995972.
- Also identified by DOI 10.1016/j.cell.2014.06.018.
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Abstract
The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.
Medical subject headings
- Acetyl Coenzyme A
- Cell Nucleus
- Pyruvate Dehydrogenase Complex