Notch one up to stroma: endothelial notch prevents inflammation and myeloproliferation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24996160.
- Also identified by DOI 10.1016/j.stem.2014.06.010.
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Abstract
In this issue of Cell Stem Cell, Wang et al. (2014) describe a signaling axis present in bone marrow stromal cells that suppresses inflammation and myeloid expansions. Loss of endothelial Notch signaling leads to deregulation of miR-155 expression, activation of NF-kB, and increased proinflammatory cytokine production, which promotes a myeloproliferative phenotype.
Medical subject headings
- Bone Marrow
- Hematologic Neoplasms
- MicroRNAs
- Myeloproliferative Disorders
- Receptors, Notch