Your heart on a chip: iPSC-based modeling of Barth-syndrome-associated cardiomyopathy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24996164.
- Also identified by DOI 10.1016/j.stem.2014.06.015.
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Abstract
Disease-specific induced pluripotent stem cells (iPSCs) are invaluable tools for studying genetic disorders in a dish. A recent paper by Wang et al. (2014) powerfully combines analysis of human iPSCs with genome editing and tissue engineering, in conjunction with biochemical and physiological assays, to provide insights into Barth-syndrome-associated cardiomyopathy.
Medical subject headings
- Barth Syndrome
- Cardiomyopathy, Dilated
- Induced Pluripotent Stem Cells
- Mitochondrial Diseases
- Models, Biological
- Tissue Engineering
- Transcription Factors