Immune modulation of stem cells and regeneration.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24996166.
- Also identified by DOI 10.1016/j.stem.2014.06.009 and PMC identifier 4131296.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The immune system, best known as the first line of defense against invading pathogens, is integral to tissue development, homeostasis, and wound repair. In recent years, there has been a growing appreciation that cellular and humoral components of the immune system also contribute to regeneration of damaged tissues, including limbs, skeletal muscle, heart, and the nervous system. Here, we discuss key findings that implicate inflammatory cells and their secreted factors in tissue replacement after injury via stem cells and other reparative mechanisms. We highlight clinical conditions that are amenable to immune-mediated regeneration and suggest immune targeting strategies for tissue regeneration.
Medical subject headings
- Heart
- Immune System
- Muscle, Skeletal
- Nervous System
- Stem Cells