Mobile DNA elements in the generation of diversity and complexity in the brain.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25005482.
- Also identified by DOI 10.1038/nrn3730 and PMC identifier 4443810.
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Abstract
Mobile elements are DNA sequences that can change their position (retrotranspose) within the genome. Although its biological function is largely unappreciated, DNA derived from mobile elements comprises nearly half of the human genome. It has long been thought that neuronal genomes are invariable; however, recent studies have demonstrated that mobile elements actively retrotranspose during neurogenesis, thereby creating genomic diversity between neurons. In addition, mounting data demonstrate that mobile elements are misregulated in certain neurological disorders, including Rett syndrome and schizophrenia.
Medical subject headings
- Brain
- DNA Transposable Elements
- Neurons
- Retroelements