DAMASCENE and Meta-Ecological Research: A Bridge Too Far.
Where this comes from
- Record sourced from PubMed, PMID 25006188.
- Also identified by DOI 10.1161/CIRCRESAHA.114.304767 and PMC identifier 4288029.
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Abstract
Population level studies commonly induce the ecological fallacy i.e., the belief that a relationship identified at the population level implies a cause and effect relationship at the level of the individual. A recent research report (DAMASCENE) that related clinical trial effect sizes in cardiovascular cell therapy trials to reporting discrepancies in the trials themselves has compounded meta-analysis difficulties with ecological fallacy issues. This dangerous combination has produced misleading conclusions and speculation that the research community should set aside.
Medical subject headings
- Bone Marrow Transplantation
- Cardiovascular Diseases
- Epidemiologic Research Design
- Evidence-Based Medicine
- Meta-Analysis as Topic
- Stem Cell Transplantation