LRRK2 parkinsonism in Tunisia and Norway: a comparative analysis of disease penetrance.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 25008396.
- Also identified by DOI 10.1212/WNL.0000000000000675 and PMC identifier 4142000.
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Abstract
In recent years, the molecular etiology of parkinsonism has yielded to genetic analysis.<sup>1</sup> Mutations in the gene leucine-rich repeat kinase 2 (<i>LRRK2</i>) have the highest genotypic and population attributable risk. Disparate penetrance estimates have been reported using a variety of statistical analyses, ethnic populations, and sample sizes.<sup>2</sup> We compared the age-associated cumulative incidence (penetrance) of <i>LRRK2</i> p.G2019S patients from Tunisia and Norway.
Medical subject headings
- Parkinsonian Disorders
- Penetrance
- Protein Serine-Threonine Kinases