repfdr: a tool for replicability analysis for genome-wide association studies.

Abstract

Identification of single nucleotide polymorphisms that are associated with a phenotype in more than one study is of great scientific interest in the genome-wide association studies (GWAS) research. The empirical Bayes approach for discovering whether results have been replicated across studies was shown to be a reliable method, and close to optimal in terms of power. The R package repfdr provides a flexible implementation of the empirical Bayes approach for replicability analysis and meta-analysis, to be used when several studies examine the same set of null hypotheses. The usefulness of the package for the GWAS community is discussed. The R package repfdr can be downloaded from CRAN. ruheller@gmail.com Supplementary data are available at Bioinformatics online.