The contraction of time and space in remote chromosomal interactions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25036625.
- Also identified by DOI 10.1016/j.cell.2014.06.039 and PMC identifier 4258836.
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Abstract
Lucas et al. report the visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B cells. Despite the huge distances separating V coding sequences from D-J sequences (~2 Mb), the authors document an astonishingly rapid rate of remote associations. The key to speed is contraction of the Igh chromosomal domain. These findings provide a foundation for understanding long-range regulatory interactions in a variety of developmental processes, including the patterning of vertebrate limbs.
Medical subject headings
- Immunoglobulin Heavy Chains
- V(D)J Recombination