Microtubule self-organization via protein-RNA network crosstalk.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25036626.
- Also identified by DOI 10.1016/j.cell.2014.06.044.
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Abstract
Microtubule plus-end tracking proteins are crucial for the regulation of microtubule dynamics. Preitner et al. report that one such protein, adenomatous polyposis coli (APC), also binds RNA and identify mRNAs encoding tubulin subunits within the brain APC-RNA interactome, suggesting a new mode of microtubule self-regulation.
Medical subject headings
- Adenomatous Polyposis Coli Protein
- Microtubules
- Neurogenesis
- RNA-Binding Proteins