γ-Secretase: a horseshoe structure brings good luck.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25036627.
- Also identified by DOI 10.1016/j.cell.2014.06.043.
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Abstract
The intramembrane protease γ-secretase is a key player in signaling and Alzheimer's disease, but its structural features have remained obscure. A structure reported recently reveals a horseshoe-shaped arrangement of 19 transmembrane helices and an extracellular domain positioned for substrate recognition. This advance bodes well for a finer resolution before long.
Medical subject headings
- Amyloid Precursor Protein Secretases
- Models, Molecular