Genetic association signal near NTN4 in Tourette syndrome.
meta_analysis · Level I
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- Record sourced from PubMed, PMID 25042818.
- Also identified by DOI 10.1002/ana.24215 and PMC identifier 4140987.
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Abstract
Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10(-4) ) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10(-7) ). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles.
Medical subject headings
- Genome-Wide Association Study
- Nerve Growth Factors
- Tourette Syndrome