Cationic oligo(p-phenylene vinylene) materials for combating drug resistance of cancer cells by light manipulation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25044102.
- Also identified by DOI 10.1002/adma.201402183.
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Abstract
An unconventional strategy that can be temporally and remotely activated with light to combat the drug resistance of cancer cells is developed. A cell-membrane-anchored photosensitizer (OPV) is used to enhance anticancer drug uptake and restore toxicity in resistant cancer cells. This method recovers the activity of the already established anticancer drugs, and provides a new strategy for the development of light manipulation to combat anticancer resistance.
Medical subject headings
- Antineoplastic Agents
- Drug Resistance, Neoplasm
- Photochemotherapy
- Photosensitizing Agents
- Polyvinyls