Proteinticle/gold core/shell nanoparticles for targeted cancer therapy without nanotoxicity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25044204.
- Also identified by DOI 10.1002/adma.201401499.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
PGCS-NPs (40 nm) with excellent photo-thermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.
Medical subject headings
- Gold
- Nanoparticles
- Peptides
- Photosensitizing Agents