Bio-inspired cryo-ink preserves red blood cell phenotype and function during nanoliter vitrification.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25047246.
- Also identified by DOI 10.1002/adma.201400941 and PMC identifier 4161503.
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Abstract
Current red-blood-cell cryopreservation methods utilize bulk volumes, causing cryo-injury of cells, which results in irreversible disruption of cell morphology, mechanics, and function. An innovative approach to preserve human red-blood-cell morphology, mechanics, and function following vitrification in nanoliter volumes is developed using a novel cryo-ink integrated with a bioprinting approach.
Medical subject headings
- Bioprinting
- Cryopreservation
- Erythrocytes
- Nanotechnology
- Vitrification