Diazepam and fluoxetine decrease the stress response in zebrafish.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25054216.
- Also identified by DOI 10.1371/journal.pone.0103232 and PMC identifier 4108411.
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Abstract
The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Danio rerio. We showed that diazepam and fluoxetine inhibited the stress axis in zebrafish. Intermediate concentrations of diazepam suppressed the stress response as measured by cortisol levels, whereas fluoxetine inhibited cortisol increase at concentrations similar to those found in the environment. These data suggest that the presence of psychoactive drugs in aquatic ecosystems could cause neuroendocrine dysfunction in fish.
Medical subject headings
- Anti-Anxiety Agents
- Antidepressive Agents, Second-Generation
- Diazepam
- Fluoxetine
- Stress, Physiological
- Water Pollutants, Chemical
- Zebrafish