Development and testing of a single frequency terahertz imaging system for breast cancer detection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25055306.
- Also identified by DOI 10.1109/JBHI.2013.2267351 and PMC identifier 4110643.
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Abstract
The ability to discern malignant from benign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.
Medical subject headings
- Breast Neoplasms
- Histocytochemistry
- Image Interpretation, Computer-Assisted
- Terahertz Imaging