Science to practice: can intravoxel incoherent motion diffusion-weighted MR imaging be used to assess tumor response to antivascular drugs?
Where this comes from
- Record sourced from PubMed, PMID 25058129.
- Also identified by DOI 10.1148/radiol.14140714.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In the study by Joo et al (1), perfusion-sensitive parameters derived from diffusion-weighted (DW) magnetic resonance (MR) imaging using intravoxel incoherent motion (IVIM) analysis were significantly decreased 4 hours after administration of a vascular disrupting agent (VDA) (CKD-516), in keeping with drug-induced vascular collapse. A larger decrease in the perfusion-sensitive IVIM parameters was correlated with smaller tumor size increase 7 days after treatment.
Medical subject headings
- Angiogenesis Inhibitors
- Benzophenones
- Diffusion Magnetic Resonance Imaging
- Liver Neoplasms, Experimental
- Neovascularization, Pathologic
- Valine