Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25065977.
- Also identified by DOI 10.1016/j.cell.2014.06.022 and PMC identifier 4150607.
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Abstract
Development of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by vaccines is a priority. Determining the steps of bnAb induction in HIV-1-infected individuals who make bnAbs is a key strategy for immunogen design. Here, we study the B cell response in a bnAb-producing individual and report cooperation between two B cell lineages to drive bnAb development. We isolated a virus-neutralizing antibody lineage that targeted an envelope region (loop D) and selected virus escape mutants that resulted in both enhanced bnAb lineage envelope binding and escape mutant neutralization-traits associated with increased B cell antigen drive. Thus, in this individual, two B cell lineages cooperated to induce the development of bnAbs. Design of vaccine immunogens that simultaneously drive both helper and broadly neutralizing B cell lineages may be important for vaccine-induced recapitulation of events that transpire during the maturation of neutralizing antibodies in HIV-1-infected individuals.
Medical subject headings
- AIDS Vaccines
- Antibodies, Neutralizing
- HIV Antibodies
- HIV-1