Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors.
Where this comes from
- Record sourced from PubMed, PMID 25073599.
- Also identified by DOI 10.1176/appi.ajp.2014.14010008 and PMC identifier 7081376.
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Abstract
Considerable research suggests that suicide involves effects of genes, the environment, and their interaction. Analysis of three independent data sets of post-mortem brains revealed signs of increased methylation in one particular gene, SKA2, a finding that was extended to peripheral blood samples from other cohorts of prospectively followed individuals.
Medical subject headings
- Adult
- Aged
- Anxiety
- Anxiety/genetics
- Cadaver
- Chromosomal Proteins, Non-Histone
- Chromosomal Proteins, Non-Histone/genetics
- DNA Methylation
- Epigenesis, Genetic
- Female
- Gene Expression Regulation
- Genetic Markers
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Hydrocortisone
- Hydrocortisone/metabolism
- Living Donors
- Male
- Middle Aged
- Neuroglia
- Neuroglia/metabolism
- Neurons
- Neurons/metabolism
- Predictive Value of Tests
- Prefrontal Cortex
- Prefrontal Cortex/metabolism
- Saliva
- Saliva/metabolism
- Sequence Analysis, DNA
- Stress, Psychological
- Stress, Psychological/genetics
- Suicidal Ideation
- Suicide
- Suicide, Attempted