Vitamin K and cardiovascular calcification in CKD: is patient supplementation on the horizon?
Level V
Where this comes from
- Record sourced from PubMed, PMID 25079019.
- Also identified by DOI 10.1038/ki.2014.24.
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Abstract
The vitamin K-dependent proteins (VKDPs) matrix Gla protein and osteocalcin protect from cardiovascular calcifications and bone fractures. A vitamin K recycling system maintains sufficient vitamin K levels for activation of VKDPs through γ-glutamyl carboxylase (GGCX). Kaesler et al. demonstrate that uremia per se can interfere with GGCX activity, contributing to vitamin K deficiency in chronic kidney disease and opening the path to the clinical use of vitamin K, currently tested in randomized trials.
Medical subject headings
- Uremia
- Vitamin K