Transcription. Comment on "Mechanism of eukaryotic RNA polymerase III transcription termination".
Level V
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- Record sourced from PubMed, PMID 25082694.
- Also identified by DOI 10.1126/science.1253783 and PMC identifier 4157655.
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Abstract
Nielsen et al. (Reports, 28 June 2013, p. 1577) characterized their RNA polymerase III (Pol III) preparation and concluded that it requires an RNA hairpin/duplex structure for terminating transcription. We could not corroborate their findings using bona fide Pol III from two laboratory sources. We show that Pol III efficiently terminates transcription in the absence of a hairpin/duplex in vitro and in vivo.
Medical subject headings
- RNA Polymerase III
- Saccharomyces cerevisiae
- Transcription Termination, Genetic