Transcription. Response to Comment on "Mechanism of eukaryotic RNA polymerase III transcription termination".
other · Level V
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- Record sourced from PubMed, PMID 25082695.
- Also identified by DOI 10.1126/science.1254246 and PMC identifier 4629412.
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Abstract
Arimbasseri et al., in their Comment, suggest that to terminate transcription in vivo, RNA polymerase III uses a mechanism other than hairpin-dependent termination and that properties of purified polymerase may depend on preparation procedure. Evidence suggests that our preparation is indeed different from that of other methods. Our new data suggest that, apart from hairpin-dependent termination, one or more "fail-safe" termination mechanisms may exist in the cell.
Medical subject headings
- RNA Polymerase III
- Saccharomyces cerevisiae
- Transcription Termination, Genetic