B cell liaison confounds HIV-1 evolution.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25083862.
- Also identified by DOI 10.1016/j.cell.2014.07.018.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
B cells expressing potent and broadly neutralizing antibodies to HIV-1 have been found in many infected individuals, suggesting that adaptive immunity has the capacity to defeat viral escape. Gao et al. uncover an intermediate stage in this process when viral escape from one "helper" B cell lineage selects variants that drive a separate B cell lineage toward broad neutralization.
Medical subject headings
- AIDS Vaccines
- Antibodies, Neutralizing
- HIV Antibodies
- HIV-1