microManaging mitochondrial translation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25083863.
- Also identified by DOI 10.1016/j.cell.2014.07.010.
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Abstract
Regulation of gene expression in mammalian mitochondria by microRNAs is reported by Zhang et al. During muscle cell differentiation, localization of a miRNA is increased within mitochondria, where it interacts with Ago2 to selectively activate translation of mtDNA-encoded mRNAs. The findings represent a new mitochondrial regulatory pathway and a potentially powerful means to purposefully manipulate mtDNA expression.
Medical subject headings
- Cell Differentiation
- MicroRNAs
- Mitochondria
- Myoblasts
- Myocytes, Cardiac
- Protein Biosynthesis