Chance, destiny, and the inner workings of ClpXP.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25083864.
- Also identified by DOI 10.1016/j.cell.2014.07.009 and PMC identifier 4945115.
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Abstract
AAA+ proteases are responsible for protein degradation in all branches of life. Using single-molecule and ensemble assays, Cordova et al. investigate how the bacterial protease ClpXP steps through a substrate's polypeptide chain and construct a quantitative kinetic model that recapitulates the interplay between stochastic and deterministic behaviors of ClpXP.
Medical subject headings
- Endopeptidase Clp